Bladder cancer is a heterogeneous disease and occupies highest incidence in developed country. There are over 70,000 new cases of bladder cancer each year in the United States alone. The incidence of bladder cancer rises with age, peakingbetween age 50 years and 70 years, and is three times more common in men than in women . The high rate of recurrence is the feature of bladder cancer that makes effective detection means is crucial importance for bladder cancer patients.
The conventional method for bladder cancer detection is morphological examination of cytology samples or cystoscopic biopsies. Urine cytology is poorly differentiated tumors and time-consuming practice for both the patient and physician. The diagnosis and monitoring of bladder cancer are facilitated by the availability of newer, simpler urine based diagnostic tests.
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