MicroRNAs are the group of single stranded non-coding RNAs of 24-31 nucleotides length which play very important role in gene regulation. They bind with protein coding genes (mRNAs) and may cause either a repressed translation or mRNA decay. Thus, the intended function of mRNA may get affected and can lead to progression/suppression of several diseases. At present, sufficient and strong evidences are available for its regulatory role in human diseases such as neurological disorders, cardiac problems and many versions of cancer.
The location where microRNA gets attached with mRNA is called binding site or target site. To design a powerful tool to study the biology of diseases connected with microRNAs, pathways that are associated with the prognosis/progression of diseases are indispensable.
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