Association between Pulse Wave Velocity and the Framingham Risk Score in Patients with different Glucose Metabolism Status

By the end of 2013, diabetes had caused 5.1 million deaths and cost billions for healthcare spending. Without concerted action to prevent diabetes, there will be 592 million people living with the disease in less than 25 years’ time. CVD is the major cause of mortality and morbidity inpatients with type 2 diabetes. The clinical relevance of this metabolic syndrome is related to its role in the development of vascular disease, including endothelium impair, an increase in arterial stiffness and intima-media thickness. Diabetes mellitus and impaired fasting glucose bring carotid arterioles atherosclerosis and hence draw our attention. PWV can intelligently show the flexible degree of aorta blood vessel, and is the gold standard evaluating atherosclerosis. 

The research is to investigate the relationship between different glucose metabolism status and PWVand further explore its relationship between PWV, HOMA-IR and FRS. Pre-diabetes has been first described by the WHOin 1980 as impaired glucose tolerance (IGT). In order to avoid the time-consuming and somewhat cumbersome measurement of 2h PG, the ADA proposed to identify pre-diabetes as impaired fasting glucose (IFG) in 1997, which relies on one fasting measurement only. In 2004, the ADA lowered the cutoff point for IFG from 6.1 to 5.6 mmol/l. IFG and IGT are strongly associated with excess body weight and insulin resistance, which is the central feature of the metabolic syndrome metabolic abnormalities and leads the path to diabetes.