Sexual dysfunction is a common side effect of
psychotropic drugs and has received much attention because of its negative
effects on quality of life and adherence to antidepressant agents. In patients
with depression, sexual dysfunction can be attributed to the underlying
disorder or to antidepressant drugs. Sexual dysfunction also can occur withfirst generation antipsychotic drugs and second-generation antipsychotic drugs
(e.g., thioridazine and risperidone, respectively). In patients with
schizophrenia, sexual dysfunction can be attributed to the underlying illness
as well as to antipsychotic induced hyperprolactinemia due to dopamine blockade
in tuberoinfundibular pathway .
Sexual behavior in humans is influenced by dopamine (DA)
and serotonin (5-HT) neurotransmission. In general, DA enhances, whereas 5-HT
inhibits, sexual motivation and performance and thus may contribute toinitiation and satiety, respectively. Dopamine has enabling effects on sexual
motivation, copulatory competence, and genital reflexes.
No comments:
Post a Comment