Obesity is a multifaceted condition and represents a
pandemic that needs urgent attention. Obesity, both directly and indirectly,
increases the risk for a variety of disease conditions including diabetes,
hypertension, liver disease, and certain cancers, which in turn, decreases the
overall lifespan in both men and women. Leptin most likely indicates satietyand fullness of energy stores under physiological conditions, but obesity is
characterized by hyperleptinemia and hypothalamic leptin resistance. Many
studies have found association between obesity leading to oxidative stress and
diabetes mellitus type 2, and many others have shown that the level of ROS
increase in obesity.
Glutathione is a master antioxidant cellular defense,
prevent damage to the important components caused by ROS such as free radicals
and peroxide. Oxidative stress is an imbalance between oxidant and antioxidant
pathways that result in the accumulation of lipid oxidation products such as
lipid hydro peroxides and malondialdehyde. These materials are toxic and causeincreased risk of arteriosclerosis in the blood by other lipoproteins. In
addition, increased oxidative stress in adults after exercise increases, It has
been shown that aerobic exercise reduces oxidative stress in obese men.
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