Fecal
coliform bacteria (FCB) are the most common microbiological contaminants of
natural waters. Fecal coliform live in the digestive tracks of warm-blooded
animals, including humans, and are excreted in the feces. Although most ofthese bacteria are not harmful and are part of the normal digestive system,some are pathogenic to humans. Those that are pathogenic can cause disease such
as gastroenteritis, ear infections, typhoid, dysentery, hepatitis A, and
cholera. The biological analysis of mice blood samples is used to investigate
the significant variations in the levels of some important compounds in the
blood which act as a laboratory indication to the presence of defects in the
physiological activities of the liver which normally accompany administration
of pathogenic substances to the animal.
The liver normal function is to
metabolize, synthesize and/or degrade both absorbed and circulating products,
and this function places it in potentially direct contact with gut-driven
bacteria. Scientists in their toxicity tests normally depend on the biochemical
analysis of blood characters for observation of any significant variations in
concentration of some important compounds which work as clinical indicators of
disturbances that take place in the physiological functions of the liver.
Studies by Lichtman et al. Suggested that intestinal bacterial overgrowth or
infection with helicobacter alone contributed to hepatic pathological change
including increased serum Alanine aminotransferase (ALT) release and
inflammatory cell recruitment.(Read more)
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