Integrins Contributes to Innate Immune Response in Pelteobagrus Fulvidraco

Integrins are mediating cell - cell, cell - matrix, cytoplasmic extracellular matrix interactions and bidirectional signal transduction between the cytosol, which contain type α and β subunits bidirectional signal non - covalent binding of formed between the transduced cell surface heterodimer. Integrins contain 24 different α and β heterodimersreceptors. The expression profile of integrins on cancer cells and the composition and organization of extracellular matrix (ECM) of the tumor stroma are major factors in therapy resistance, metastasis and cancer development. Collagen is the most abundant ECM protein in vertebrate organisms, forming the framework of connective tissues and soft interstitial matrices (such as the bone marrow), and is also a critical matrix of the tumor microenvironment.

Integrins - β1, associate with 12 different α subunits, is the largest sub - family of integrins. Integrin - β1, as a major collagenreceptor, is widely expressed and known to promote cell migration and controltissue homeostasis. Integrin - β1 can either inhibit or promote the cancer cells dissemination process and cancer metastasis regulator.