Variety of Neuronal Pathways to Achieve the Same Hypoxic Preconditioning Effect

The relevance of hypoxic preconditioning is due to its ability to increase the body's resistance to hypoxic/ischemic stress. Hypoxic factor is the main inischemic preconditioning effect. It is likely that hypoxic component forms the pathogenesis of many diseases, and a study of the preconditioning mechanisms is a high priority.

In the problem of hypoxic adaptation, the brain is central, not only as the most sensitive organ to hypoxia, but also as the coordinator of functions of all body organs and systems. In the nervous tissue, the functional specificity and individualsensitivity to hypoxia of separate neuronal populations and the corresponding brain structures is of fundamental importance. The structures of forebrain are most unstable to ischaemic/hypoxic injuries. The most interesting are the cortex and hippocampus, as these are the higher brain structures responsible for cognitive functions and complex behaviour.